Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications
نویسندگان
چکیده
Successful delivery of irf5-siRNA by PEI-LBL-NCs resulted macrophages phenotype change from the M1 to M2 and accelerated wound healing.
منابع مشابه
Blocking Interleukin-1β Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes
Diabetes is associated with persistent inflammation and defective tissue repair responses. The hypothesis of this study was that interleukin (IL)-1β is part of a proinflammatory positive feedback loop that sustains a persistent proinflammatory wound macrophage phenotype that contributes to impaired healing in diabetes. Macrophages isolated from wounds in diabetic humans and mice exhibited a pro...
متن کاملBlocking IL-1β Induces a Healing-associated Wound Macrophage Phenotype and Improves Healing in Type-2 Diabetes
متن کامل
Blocking Interleukin-1b Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes
Diabetes is associated with persistent inflammation and defective tissue repair responses. The hypothesis of this study was that interleukin (IL)-1b is part of a proinflammatory positive feedback loop that sustains a persistent proinflammatory wound macrophage phenotype that contributes to impaired healing in diabetes. Macrophages isolated from wounds in diabetic humans and mice exhibited a pro...
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ژورنال
عنوان ژورنال: Nanoscale
سال: 2021
ISSN: ['2040-3372', '2040-3364']
DOI: https://doi.org/10.1039/d1nr03830c